Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha.

In response to decreased cellular oxygen concentrations the basic helix-loop-helix (bHLH)/PAS (Per, Arnt, Sim) hypoxia-inducible transcription factor, HIF-1alpha, mediates activation of networks of target genes involved in angiogenesis, erythropoiesis and glycolysis. Here we demonstrate that the mec...

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Main Authors: Kallio, P J, Okamoto, K, O'Brien, S, Carrero, P, Makino, Y, Tanaka, H, Poellinger, L
Format: Artigo
Jezik:Inglês
Izdano: 1998
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171004/
https://ncbi.nlm.nih.gov/pubmed/9822602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.22.6573
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