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A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.

The ubiquitin proteolytic pathway is a major system for selective protein degradation in eukaryotic cells. One of the first steps in the degradation of a protein via this pathway involves selective modification of epsilon-NH2 groups of internal lysine residues by ubiquitination. To date, this amino...

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Détails bibliographiques
Auteurs principaux: Breitschopf, K, Bengal, E, Ziv, T, Admon, A, Ciechanover, A
Format: Artigo
Langue:Inglês
Publié: 1998
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170923/
https://ncbi.nlm.nih.gov/pubmed/9774340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.20.5964
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