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Mechanism of inhibition of Psi+ prion determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein.

The SUP35 gene of Saccharomyces cerevisiae encodes the polypeptide chain release factor eRF3. This protein (also called Sup35p) is thought to be able to undergo a heritable conformational switch, similarly to mammalian prions, giving rise to the cytoplasmically inherited Psi+ determinant. A dominant...

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Autori principali: Kochneva-Pervukhova, N V, Paushkin, S V, Kushnirov, V V, Cox, B S, Tuite, M F, Ter-Avanesyan, M D
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170908/
https://ncbi.nlm.nih.gov/pubmed/9755180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.19.5805
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