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Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing.
Among the spliceosomal snRNAs, U2 has the most extensive modifications, including a 5' trimethyl guanosine (TMG) cap, ten 2'-O-methylated residues and 13 pseudouridines. At short times after injection, cellularly derived (modified) U2 but not synthetic (unmodified) U2 rescues splicing in X...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1998
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170906/ https://ncbi.nlm.nih.gov/pubmed/9755178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.19.5783 |
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