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Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.
We have shown previously that the heavy metal-responsive transcriptional activator MTF-1 regulates the basal and heavy metal-induced expression of metallothioneins. To investigate the physiological function of MTF-1, we generated null mutant mice by targeted gene disruption. Embryos lacking MTF-1 di...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
1998
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170625/ https://ncbi.nlm.nih.gov/pubmed/9582278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.10.2846 |
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