Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.

SPARC (secreted protein acidic and rich in cysteine, also known as osteonectin/BM40) is a secreted Ca2+-binding glycoprotein that interacts with a range of extracellular matrix molecules, including collagen IV. It is widely expressed during embryogenesis, and in vitro studies have suggested roles in...

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Bibliographic Details
Main Authors:	Gilmour, D T, Lyon, G J, Carlton, M B, Sanes, J R, Cunningham, J M, Anderson, J R, Hogan, B L, Evans, M J, Colledge, W H
Format:	Artigo
Language:	Inglês
Published:	1998
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1170533/ https://ncbi.nlm.nih.gov/pubmed/9524110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.7.1860
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Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.

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