Pentamidine inhibits catalytic activity of group I intron Ca.LSU by altering RNA folding

The antimicrobial agent pentamidine inhibits the self-splicing of the group I intron Ca.LSU from the transcripts of the 26S rRNA gene of Candida albicans, but the mechanism of pentamidine inhibition is not clear. We show that preincubation of the ribozyme with pentamidine enhances the inhibitory eff...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Zhang, Yi, Li, Zhijie, Pilch, Daniel S., Leibowitz, Michael J.
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2002
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117049/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12087182/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf394
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