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Different positioning of the ligand-binding domain helix 12 and the F domain of the estrogen receptor accounts for functional differences between agonists and antagonists.

The estrogen receptor is capable of binding a diverse set of ligands that are broadly categorized as agonists or antagonists, depending on their abilities to induce or interfere with transcriptional responsiveness. We show, using a fusion protein assay for ligand-binding which does not rely on trans...

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Bibliografiske detaljer
Main Authors: Nichols, M, Rientjes, J M, Stewart, A F
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170425/
https://ncbi.nlm.nih.gov/pubmed/9451001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.3.765
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