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Modulation of the intracellular stability and toxicity of diphtheria toxin through degradation by the N-end rule pathway.
The enzymatically active A-fragment of diphtheria toxin enters the cytosol of sensitive cells where it inhibits protein synthesis by inactivating elongation factor 2 (EF-2). We have constructed a number of diphtheria toxin mutants that are degraded by the N-end rule pathway in Vero cells, and that d...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170411/ https://ncbi.nlm.nih.gov/pubmed/9430652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.2.615 |
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