Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death.

Yeast rad51 mutants are viable, but extremely sensitive to gamma-rays due to defective repair of double-strand breaks. In contrast, disruption of the murine RAD51 homologue is lethal, indicating an essential role of Rad51 in vertebrate cells. We generated clones of the chicken B lymphocyte line DT40...

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Detalhes bibliográficos
Main Authors: Sonoda, E, Sasaki, M S, Buerstedde, J M, Bezzubova, O, Shinohara, A, Ogawa, H, Takata, M, Yamaguchi-Iwai, Y, Takeda, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170409/
https://ncbi.nlm.nih.gov/pubmed/9430650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.2.598
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