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Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels.

The activation of cyclic nucleotide-gated (CNG) channels is a complex process comprising the initial ligand binding and a consecutive allosteric transition from a closed to an open configuration. The cone and olfactory CNG channels differ considerably in cyclic nucleotide affinity and efficacy. In e...

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Bibliografski detalji
Glavni autori: Zong, X, Zucker, H, Hofmann, F, Biel, M
Format: Artigo
Jezik:Inglês
Izdano: 1998
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170386/
https://ncbi.nlm.nih.gov/pubmed/9430627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.2.353
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