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Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels.
The activation of cyclic nucleotide-gated (CNG) channels is a complex process comprising the initial ligand binding and a consecutive allosteric transition from a closed to an open configuration. The cone and olfactory CNG channels differ considerably in cyclic nucleotide affinity and efficacy. In e...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1998
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170386/ https://ncbi.nlm.nih.gov/pubmed/9430627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.2.353 |
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