The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.

The MLK (mixed lineage) ser/thr kinases are most closely related to the MAP kinase kinase kinase family. In addition to a kinase domain, MLK1, MLK2 and MLK3 each contain an SH3 domain, a leucine zipper domain and a potential Rac/Cdc42 GTPase-binding (CRIB) motif. The C-terminal regions of the protei...

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Bibliographic Details
Main Authors: Nagata, K, Puls, A, Futter, C, Aspenstrom, P, Schaefer, E, Nakata, T, Hirokawa, N, Hall, A
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170366/
https://ncbi.nlm.nih.gov/pubmed/9427749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.1.149
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