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Changes in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model.

Mice that express influenza hemagglutinin under control of the rat insulin promoter (INS-HA) as well as a class II major histocompatibility complex (MHC)-restricted HA-specific transgenic TCR (TCR-HA), develop early insulitis with huge infiltrates, but progress late and irregularly to diabetes. Init...

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Main Authors: Sarukhan, A, Lanoue, A, Franzke, A, Brousse, N, Buer, J, von Boehmer, H
Format: Artigo
Jezik:Inglês
Izdano: 1998
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170359/
https://ncbi.nlm.nih.gov/pubmed/9427742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.1.71
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