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Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.

A cDNA was cloned that encodes human stress-activated protein kinase-4 (SAPK4), a novel MAP kinase family member whose amino acid sequence is approximately 60% identical to that of the other three SAP kinases which contain a TGY motif in their activation domain. The mRNA encoding SAPK4 was found to...

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Autors principals: Goedert, M, Cuenda, A, Craxton, M, Jakes, R, Cohen, P
Format: Artigo
Idioma:Inglês
Publicat: 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169981/
https://ncbi.nlm.nih.gov/pubmed/9218798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.12.3563
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