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Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.
Parasitic protozoa belonging to the order Kinetoplastida contain trypanothione as their major thiol. Trypanothione reductase (TR), the enzyme responsible for maintaining trypanothione in its reduced form, is thought to be central to the redox defence systems of trypanosomatids. To investigate furthe...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169870/ https://ncbi.nlm.nih.gov/pubmed/9184206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.10.2590 |
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