טוען...
Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage.
Activation of furin requires autoproteolytic cleavage of its 83-amino acid propeptide at the consensus furin site, Arg-Thr-Lys-Arg107/. This RER-localized cleavage is necessary, but not sufficient, for enzyme activation. Rather, full activation of furin requires exposure to, and correct routing with...
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| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
1997
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169755/ https://ncbi.nlm.nih.gov/pubmed/9130696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.7.1508 |
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