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Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine.
The oestrogen receptor is a member of the nuclear receptor family of transcription factors which, on binding the steroid hormone 17beta-oestradiol, interacts with co-activator proteins and stimulates gene expression. Replacement of a single tyrosine in the hormone-binding domain generated activated...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169739/ https://ncbi.nlm.nih.gov/pubmed/9135157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.6.1427 |
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