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The role of the PH domain in the signal-dependent membrane targeting of Sos.
The pleckstrin homology (PH) domain is a conserved protein module present in diverse signal transducing proteins. To investigate the function of the PH domain of the Ras exchanger Sos, we have generated a recombinant (His)6-tagged PH domain from human Sos1 (PH-Sos). Here we show that PH-Sos binds wi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1997
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169732/ https://ncbi.nlm.nih.gov/pubmed/9135150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.6.1351 |
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