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The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.

The ATP-sensitive K-channel (K-ATP channel) plays a key role in insulin secretion from pancreatic beta-cells. It is closed by glucose metabolism, which stimulates insulin secretion, and opened by the drug diazoxide, which inhibits insulin release. Metabolic regulation is mediated by changes in ATP a...

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Sonraí Bibleagrafaíochta
Main Authors: Gribble, F M, Tucker, S J, Ashcroft, F M
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1997
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169713/
https://ncbi.nlm.nih.gov/pubmed/9135131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.6.1145
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