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Both the isomerase and chaperone activities of protein disulfide isomerase are required for the reactivation of reduced and denatured acidic phospholipase A2.

The spontaneous reactivation yield of acidic phospholipase A2 (APLA2), a protein containing seven disulfide bonds, after reduction and denaturation in guanidine hydrochloride is very low. Protein disulfide isomerase (PDI) markedly increases the reactivation yield and prevents the aggregation of APLA...

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Bibliografische gegevens
Hoofdauteurs: Yao, Y, Zhou, Y, Wang, C
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1997
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169667/
https://ncbi.nlm.nih.gov/pubmed/9034346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.3.651
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