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Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation.

Many cellular signaling proteins contain SH3 (Src homology 3) domains that mediate protein interactions via specific proline-containing peptides. Unlike SH2 domains, whose interactions with tyrosine-containing peptides are promoted by phosphorylation of the SH2 binding site, the regulatory mechanism...

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Bibliografiske detaljer
Main Authors: Hu, K Q, Settleman, J
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169651/
https://ncbi.nlm.nih.gov/pubmed/9034330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.3.473
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