Cardiac Tissue-Specific Repression of CELF Activity Disrupts Alternative Splicing and Causes Cardiomyopathy

Members of the CELF family of RNA binding proteins have been implicated in alternative splicing regulation in developing heart. Transgenic mice that express a nuclear dominant-negative CELF protein specifically in the heart (MHC-CELFΔ) develop cardiac hypertrophy and dilated cardiomyopathy with defe...

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Detalhes bibliográficos
Main Authors: Ladd, Andrea N., Taffet, George, Hartley, Craig, Kearney, Debra L., Cooper, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168813/
https://ncbi.nlm.nih.gov/pubmed/15988035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.14.6267-6278.2005
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