Cardiac Tissue-Specific Repression of CELF Activity Disrupts Alternative Splicing and Causes Cardiomyopathy

Members of the CELF family of RNA binding proteins have been implicated in alternative splicing regulation in developing heart. Transgenic mice that express a nuclear dominant-negative CELF protein specifically in the heart (MHC-CELFΔ) develop cardiac hypertrophy and dilated cardiomyopathy with defe...

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Bibliographische Detailangaben
Hauptverfasser: Ladd, Andrea N., Taffet, George, Hartley, Craig, Kearney, Debra L., Cooper, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168813/
https://ncbi.nlm.nih.gov/pubmed/15988035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.14.6267-6278.2005
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