Human Tripartite Motif 5α Domains Responsible for Retrovirus Restriction Activity and Specificity

The tripartite motif 5α protein (TRIM5α) is one of several factors expressed by mammalian cells that inhibit retrovirus replication. Human TRIM5α (huTRIM5α) inhibits infection by N-tropic murine leukemia virus (N-MLV) but is inactive against human immunodeficiency virus type 1 (HIV-1). However, we s...

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Detalhes bibliográficos
Main Authors: Perez-Caballero, David, Hatziioannou, Theodora, Yang, Annie, Cowan, Simone, Bieniasz, Paul D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168745/
https://ncbi.nlm.nih.gov/pubmed/15994791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.8969-8978.2005
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