Structural Diversity of Streptokinase and Activation of Human Plasminogen

The β domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative f...

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Bibliographic Details
Main Authors: Lizano, Sergio, Johnston, Kenneth H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168554/
https://ncbi.nlm.nih.gov/pubmed/15972548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.7.4451-4453.2005
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