Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

1. Monochloroacetate, dichloroacetate, trichloroacetate, difluoroacetate, 2-chloropropionate, 2,2′-dichloropropionate and 3-chloropropionate were inhibitors of pig heart pyruvate dehydrogenase kinase. Dichloroacetate was also shown to inhibit rat heart pyruvate dehydrogenase kinase. The inhibition w...

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Bibliographic Details
Main Authors: Whitehouse, Sue, Cooper, Ronald H., Randle, Philip J.
Format: Artigo
Language:Inglês
Published: 1974
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168183/
https://ncbi.nlm.nih.gov/pubmed/4478069
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