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Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells
Cumulative evidence indicates that breast cancer-associated gene 1 (BRCA1) participates in DNA damage repair and cell-cycle checkpoint control, serving as a tumor susceptibility gene to maintain the global genomic stability. However, whether BRCA1 has a direct role in cell proliferation and differen...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1166629/ https://ncbi.nlm.nih.gov/pubmed/15967981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503793102 |
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