α(1)-Adrenoceptor stimulation potentiates L-type Ca(2+) current through Ca(2+)/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes

α(1)-Adrenoceptor stimulation (α(1)ARS) modulates cardiac muscle contraction under physiological conditions by means of changes in Ca(2+) current through L-type channels (I(Ca,L)) and Ca(2+) ensitivity of the myofilaments. However, the cellular mechanisms of α(1)ARS are not fully clarified. In this...

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Bibliographic Details
Main Authors: O-Uchi, Jin, Komukai, Kimiaki, Kusakari, Yoichiro, Obata, Toru, Hongo, Kenichi, Sasaki, Hiroyuki, Kurihara, Satoshi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1166620/
https://ncbi.nlm.nih.gov/pubmed/15964981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503569102
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