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The evolution of human anti-double-stranded DNA autoantibodies
It has been proposed that the anti-double-stranded DNA (dsDNA) response in patients with systemic lupus erythematosus (SLE) is antigen driven and that DNA or nucleosomes select anti-DNA reactive, somatically mutated B cells. We have used site-directed mutagenesis to systematically revert the somatic...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2005
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1166593/ https://ncbi.nlm.nih.gov/pubmed/15968001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500132102 |
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