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The evolution of human anti-double-stranded DNA autoantibodies

It has been proposed that the anti-double-stranded DNA (dsDNA) response in patients with systemic lupus erythematosus (SLE) is antigen driven and that DNA or nucleosomes select anti-DNA reactive, somatically mutated B cells. We have used site-directed mutagenesis to systematically revert the somatic...

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Detalhes bibliográficos
Main Authors: Wellmann, Ute, Letz, Miriam, Herrmann, Martin, Angermüller, Sieglinde, Kalden, Joachim R., Winkler, Thomas H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1166593/
https://ncbi.nlm.nih.gov/pubmed/15968001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500132102
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