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Properties of the histidine residues of indole-chymotrypsin. Implications for the activation process and catalytic mechanism.

The use of a linear free-energy relationship shows that both histidine residues of alpha-chymotrypsin and chymotrypsinogen are super-reactive toward 1-fluoro-2,4-dinitrobenzene. The binding of indole to the specificity site of alpha-chymotrypsin causes both histidine residues to become less reactive...

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Detalles Bibliográficos
Main Authors: Cruickshank, W H, Kaplan, H
Formato: Artigo
Idioma:Inglês
Publicado: 1975
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1165466/
https://ncbi.nlm.nih.gov/pubmed/241327
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