Differences in the Carboxy-Terminal (Putative Phospholipid Binding) Domains of Clostridium perfringens and Clostridium bifermentans Phospholipases C Influence the Hemolytic and Lethal Properties of These Enzymes

The phospholipases C of C. perfringens (alpha-toxin) and C. bifermentans (Cbp) show >50% amino acid homology but differ in their hemolytic and toxic properties. We report here the purification and characterisation of alpha-toxin and Cbp. The phospholipase C activity of alpha-toxin and Cbp was simila...

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Pubblicato in:	Infect Immun
Autori principali:	Jepson, Marie, Howells, Angela, Bullifent, Helen L., Bolgiano, Barbara, Crane, Dennis, Miller, Julie, Holley, Jane, Jayasekera, Pramukh, Titball, Richard W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Molecular and Cellular Pathogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116509/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10377104/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.7.3297-3301.1999
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