Response of Foot-and-Mouth Disease Virus to Increased Mutagenesis: Influence of Viral Load and Fitness in Loss of Infectivity

Passage of foot-and-mouth disease virus (FMDV) in cell culture in the presence of the mutagenic base analog 5-fluorouracil or 5-azacytidine resulted in decreases of infectivity and occasional extinction of the virus. Low viral loads and low viral fitness enhanced the frequency of extinction events;...

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Publié dans:	J Virol
Auteurs principaux:	Sierra, Saleta, Dávila, Mercedes, Lowenstein, Pedro R., Domingo, Esteban
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2000
Sujets:	Recombination and Evolution
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116341/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10954530/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.18.8316-8323.2000
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