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Differential inhibition of rat liver DNA polymerases in vitro by direct-acting carcinogens and the protective effect of a thiol reducing agent.

The direct-acting carcinogens acetoxyacetylaminofluorene, methylnitrosourea, and N-methyl-N'-nitro-N-nitrosoguanidine were tested for their ability to inhibit rat liver DNA polymerase-alpha, -beta, and -gamma activity in vitro. DNA polymerase-alpha was the most sensitive, polymerase-beta was th...

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Hlavní autoři: Chan, J Y, Becker, F F
Médium: Artigo
Jazyk:Inglês
Vydáno: 1981
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1162693/
https://ncbi.nlm.nih.gov/pubmed/7305970
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