Theoretical analysis of the consequences of cyclic nucleotide phosphodiesterase negative co-operativity. Amplification and positive co-operativity of cyclic AMP accumulation.

Most tissues contain multiple forms of cyclic nucleotide phosphodiesterases (3':5'-cyclic-nucleotide 5' nucleotidohydrolase, EC 3.1.4.17). Consequently, in most, if not in all, tissues, substrate-velocity curves deviate from Michaelian kinetics and exhibit an apparent negative co-oper...

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Autori principali: Erneux, C, Boeynaems, J M, Dumont, J E
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1980
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1162327/
https://ncbi.nlm.nih.gov/pubmed/6272696
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