Adaptive Mutations in the V3 Loop of gp120 Enhance Fusogenicity of Human Immunodeficiency Virus Type 1 and Enable Use of a CCR5 Coreceptor That Lacks the Amino-Terminal Sulfated Region

To identify sites in gp120 that interact with the CCR5 coreceptor and to analyze the mechanisms of infection, we selected variants of the CCR5-dependent JRCSF molecular clone of human immunodeficiency virus type 1 (HIV-1) that adapted to replicate in HeLa-CD4 cells that express the mutant coreceptor...

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Pubblicato in:	J Virol
Autori principali:	Platt, Emily J., Kuhmann, Shawn E., Rose, Patrick P., Kabat, David
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116123/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11711617/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.24.12266-12278.2001
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