Cardiac glycosides inhibit TNF-α/NF-κB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor

Digitoxin and structurally related cardiac glycoside drugs potently block activation of the TNF-α/NF-κB signaling pathway. We have hypothesized that the mechanism might be discovered by searching systematically for selective inhibitory action through the entire pathway. We report that the common act...

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Detalhes bibliográficos
Main Authors: Yang, Qingfeng, Huang, Wei, Jozwik, Catherine, Lin, Yong, Glasman, Mirta, Caohuy, Hung, Srivastava, Meera, Esposito, Dominic, Gillette, William, Hartley, James, Pollard, Harvey B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1160519/
https://ncbi.nlm.nih.gov/pubmed/15983368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504097102
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