Replication of Toxoplasma gondii, but Not Trypanosoma cruzi, Is Regulated in Human Fibroblasts Activated with Gamma Interferon: Requirement of a Functional JAK/STAT Pathway

To study the role of tryptophan degradation by indoleamine 2,3-dioxygenase (INDO) in the control of Trypanosoma cruzi or Toxoplasma gondii replication, we used human fibroblasts and a fibrosarcoma cell line (2C4). The cells were cultured in the presence or absence of recombinant gamma interferon (rI...

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Publié dans:	Infect Immun
Auteurs principaux:	Cerávolo, Isabela Penna, Chaves, Andréa C. L., Bonjardim, Cláudio A., Sibley, David, Romanha, Alvaro J., Gazzinelli, Ricardo T.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1999
Sujets:	Fungal and Parasitic Infections
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10225879/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.5.2233-2240.1999
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