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Replication of Toxoplasma gondii, but Not Trypanosoma cruzi, Is Regulated in Human Fibroblasts Activated with Gamma Interferon: Requirement of a Functional JAK/STAT Pathway

To study the role of tryptophan degradation by indoleamine 2,3-dioxygenase (INDO) in the control of Trypanosoma cruzi or Toxoplasma gondii replication, we used human fibroblasts and a fibrosarcoma cell line (2C4). The cells were cultured in the presence or absence of recombinant gamma interferon (rI...

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Detalhes bibliográficos
Main Authors: Cerávolo, Isabela Penna, Chaves, Andréa C. L., Bonjardim, Cláudio A., Sibley, David, Romanha, Alvaro J., Gazzinelli, Ricardo T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC115962/
https://ncbi.nlm.nih.gov/pubmed/10225879
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