Adenovirus Type 5 Viral Particles Pseudotyped with Mutagenized Fiber Proteins Show Diminished Infectivity of Coxsackie B-Adenovirus Receptor-Bearing Cells

A major limitation of adenovirus type 5 (Ad5)-based gene therapy, the inability to target therapeutic genes to selected cell types, is attributable to the natural tropism of the virus for the widely expressed coxsackievirus-adenovirus receptor (CAR) protein. Modifications of the Ad5 fiber knob domai...

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Autors principals: Jakubczak, John L., Rollence, Michele L., Stewart, David A., Jafari, Jonathon D., Von Seggern, Dan J., Nemerow, Glen R., Stevenson, Susan C., Hallenbeck, Paul L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC115923/
https://ncbi.nlm.nih.gov/pubmed/11222722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.6.2972-2981.2001
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