Role for Human Immunodeficiency Virus Type 1 Tat Protein in Suppression of Viral Reverse Transcriptase Activity during Late Stages of Viral Replication

We have examined the role of the human immunodeficiency virus type 1 (HIV-1) Tat protein in the regulation of reverse transcription. We show that a two-exon but not a one-exon form of Tat markedly suppressed cell-free reverse transcriptase (RT) activity. Conversely, viruses expressing two-exon Tat (...

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Main Authors: Kameoka, Masanori, Rong, Liwei, Götte, Matthias, Liang, Chen, Russell, Rodney S., Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC115892/
https://ncbi.nlm.nih.gov/pubmed/11222691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.6.2675-2683.2001
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