The role of the Zn(II) binding domain in the mechanism of E. coli DNA topoisomerase I
BACKGROUND: Escherichia coli DNA topoisomerase I binds three Zn(II) with three tetracysteine motifs which, together with the 14 kDa C-terminal region, form a 30 kDa DNA binding domain (ZD domain). The 67 kDa N-terminal domain (Top67) has the active site tyrosine for DNA cleavage but cannot relax neg...
Tallennettuna:
| Julkaisussa: | BMC Biochem |
|---|---|
| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
BMC
2002
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115839/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12052259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2091-3-13 |
| Tagit: |
Ei tageja, Lisää ensimmäinen tagi!
|