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The role of the Zn(II) binding domain in the mechanism of E. coli DNA topoisomerase I
BACKGROUND: Escherichia coli DNA topoisomerase I binds three Zn(II) with three tetracysteine motifs which, together with the 14 kDa C-terminal region, form a 30 kDa DNA binding domain (ZD domain). The 67 kDa N-terminal domain (Top67) has the active site tyrosine for DNA cleavage but cannot relax neg...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
BioMed Central
2002
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC115839/ https://ncbi.nlm.nih.gov/pubmed/12052259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-3-13 |
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