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The opioid peptide dynorphin directly blocks NMDA receptor channels in the rat.

1. The actions of dynorphin on N-methyl-D-aspartate (NMDA) responses were examined in acutely dissociated trigeminal neurons in rat. Whole-cell and single-channel currents were recorded using the patch clamp technique. 2. Dynorphins reduced NMDA-activated currents (INMDA). The IC50 was 0.25 microM f...

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Bibliografske podrobnosti
Main Authors: Chen, L, Gu, Y, Huang, L Y
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1157783/
https://ncbi.nlm.nih.gov/pubmed/7537820
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