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Receptor- and non-receptor-mediated uptake and degradation of insulin by hepatocytes
Native insulin inhibits the binding and degradation of (125)I-labelled insulin in parallel. Half-maximal inhibition of degradation occurs with 10nm-insulin, a hormone concentration sufficient to saturate the insulin receptor. The proportion of bound hormone that is degraded increases as the insulin...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1982
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1153948/ https://ncbi.nlm.nih.gov/pubmed/6760855 |
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