Des-, syn- and anti-oxyimino-delta 3-cephalosporins. Intrinsic reactivity and reaction with RTEM-2 serine beta-lactamase and D-alanyl-D-alanine-cleaving serine and Zn2+-containing peptidases.

The presence and configuration (syn or anti) of an oxyimino group in the 7 (beta)-acyl side chain of 3-cephems do not modify the intrinsic reactivity of the beta-lactam ring, but have highly enzyme-specific effects. When compared with the corresponding desoxyimino beta-lactam compound: (i) with the...

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Detalles Bibliográficos
Main Authors: Laurent, G, Durant, F, Frere, J M, Klein, D, Ghuysen, J M
Formato: Artigo
Idioma:Inglês
Publicado: 1984
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1153425/
https://ncbi.nlm.nih.gov/pubmed/6609701
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