Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins

In mammalian cells, repair of the most abundant endogenous premutagenic lesion in DNA, 7,8-dihydro-8-oxoguanine (8-oxoG), is initiated by the bifunctional DNA glycosylase OGG1. By using purified human proteins, we have reconstituted repair of 8-oxoG lesions in DNA in vitro on a plasmid DNA substrate...

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Autores principales: Pascucci, B., Maga, G., Hübscher, U., Bjoras, M., Seeberg, E., Hickson, I. D., Villani, G., Giordano, C., Cellai, L., Dogliotti, E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC115284/
https://ncbi.nlm.nih.gov/pubmed/12000832
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