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Inhibition by sporidesmin of hepatocyte bile acid transport.
Exposure of isolated rat hepatocytes (approx. 2 x 10(7)--5 x 10(7) cells/10ml of incubation mixture) to 0.5 mg of the mycotoxin sporidesmin for 30--60 min at 37 degrees C produced loss of plasma-membrane microvilli with some disruption of organelle distribution in the sub-surface region. There was a...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
1983
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1152029/ https://ncbi.nlm.nih.gov/pubmed/6870851 |
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