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Activation of NF-κB by the Human Herpesvirus 8 Chemokine Receptor ORF74: Evidence for a Paracrine Model of Kaposi's Sarcoma Pathogenesis

Infection with human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma (KS)-associated herpesvirus, is necessary for the development of KS. The HHV-8 lytic-phase gene ORF74 is related to G protein-coupled receptors, particularly interleukin-8 (IL-8) receptors. ORF74 activates the inositol phosph...

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Udgivet i:J Virol
Principais autores: Pati, Shibani, Cavrois, Marielle, Guo, Hong-Guang, Foulke, James S., Kim, Jynho, Feldman, Ricardo A., Reitz, Marvin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115111/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11507211/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.18.8660-8673.2001
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