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Critical Role for Alpha/Beta and Gamma Interferons in Persistence of Lymphocytic Choriomeningitis Virus by Clonal Exhaustion of Cytotoxic T Cells

Under conditions of high antigenic load during infection with invasive lymphocytic choriomeningitis virus (LCMV) strains, virus can persist by selective clonal exhaustion of antigen-specific CD8(+) T cells. In this work we studied the down-regulation of the virus-specific CD8(+)-T-cell response duri...

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Udgivet i:J Virol
Principais autores: Ou, Rong, Zhou, Shenghua, Huang, Lei, Moskophidis, Demetrius
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115086/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11507186/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.18.8407-8423.2001
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