Critical Role for Alpha/Beta and Gamma Interferons in Persistence of Lymphocytic Choriomeningitis Virus by Clonal Exhaustion of Cytotoxic T Cells

Under conditions of high antigenic load during infection with invasive lymphocytic choriomeningitis virus (LCMV) strains, virus can persist by selective clonal exhaustion of antigen-specific CD8(+) T cells. In this work we studied the down-regulation of the virus-specific CD8(+)-T-cell response duri...

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Bibliographic Details
Main Authors: Ou, Rong, Zhou, Shenghua, Huang, Lei, Moskophidis, Demetrius
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC115086/
https://ncbi.nlm.nih.gov/pubmed/11507186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.18.8407-8423.2001
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